AF_WGS_TOPMed_Freeze4_GWAS.txt
Summary level results for AF WES UK Biobank phase1 (European ancestry)

Publication:
Choi SH, Jurgens SJ, Weng LC, Pirruccello JP, Roselli C, Chaffin M, Lee C, Hall AW, Khera AV, Lunetta K, Lubitz SA, Ellinor PT. Monogenic and Polygenic Contributions to Atrial Fibrillation Risk: Results from a National Biobank. Circ Res. 2019 Nov 6;PubMed PMID: 31691645.


Column		Description
Gene  Genenames
N Sample size
Chr Chromosome
Position  approximated position of genes (b38)
Beta  Effect Size
SE  Standard Error
Pvalue  Pvalue (corrected for case-control imbalance)



####### R script #######
library(data.table)
man3 <- fread('/medpop/afib/projects/ukbb_50k_exome/result/rarevariant/LOF_burden/final_results_exome_LOF_AF_cMAC_10plus_adjusted_for_PGS.txt', stringsAsFactors = F, data.table = F)
man3$carrier.freq<-man3$AF*2

man4<-man3[,c("genes","N","CHR","POS","BETA","SE","p.value.NA")]
colnames(man4)<-c("Gene","N","Chr","Position","Beta","SE","pvalue")
setwd("/medpop/afib/uploads/af_portal")

write.table(man4,"AF_WES_UKBB_phase1_gene_based_LOF.txt",col.names=T,row.names=F,quote=F,sep="\t")
####### R script #######