T2D (2020)
We carried out GWAS meta-analysis (imputed to 1000G Phase 3) for type 2 diabetes in up to 433,540 East Asians. Each contributing study performed study-specific sample and variant quality control. Within each study, all variants were tested for association with T2D assuming an additive model of inheritance within a regression framework (FIRTH, mach2dat, BLOT-LMM), including age, sex, and other study-specific covariates. We then carried out fixed-effects inverse-variance weighted meta-analysis as implemented in METAL. 

The file contains association summary statistics for the AGEN T2D meta-analysis of 23 studies.

Secondary analyses files are available on http://blog.nus.edu.sg/agen/summary-statistics/t2d-2020/

The file contains the following information:

MarkerName: Chr:pos_ref/alt
Chrpos: Chr:pos
Chr: Chromosome
Pos: Position (hg19)
EA: Effect allele
NEA: Other allele
EAF: Effect allele frequency
Neff: Effective sample size
Beta: Effect estimate
SE: Standard error of effect estimate
P: P-value
Maximal sample size = 433,540
T2D_ALL_PRIMARY


Please refer any queries to Dr Xueling Sim (ephsx@nus.edu.sg)